The cover image represents the allosteric changes in the transcriptional repressor protein Staphylococcus aureus CzrA upon binding of Zn(II). As Zn(II) binds DNA bound apo-CzrA (upper right image) the DNA binding affinity is reduced by 4 orders of magnitude and the structure of CzrA switches from a “closed” conformation to an “open” conformation facilitating its release from DNA (lower left image). See http://pubs.acs.org/doi/abs/10.1021/ja208047b. Image created by M. Nihan Ucisik, Dhruva Chakravorty and Kenneth M. Merz, Jr.